Direct ubiquitination of β-catenin by Siah-1 and regulation by the exchange factor TBL1
نویسندگان
چکیده
منابع مشابه
Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1.
Beta-catenin is a key component of the Wnt signaling pathway that functions as a transcriptional co-activator of Wnt target genes. Upon UV-induced DNA damage, beta-catenin is recruited for polyubiquitination and subsequent proteasomal degradation by a unique, p53-induced SCF-like complex (SCF(TBL1)), comprised of Siah-1, Siah-1-interacting protein (SIP), Skp1, transducin beta-like 1 (TBL1), and...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2010
ISSN: 0021-9258
DOI: 10.1074/jbc.a109.049411